Bpsbioscience/Nutlin-3/27711/5毫克
商品编号：
27711
品牌：
bpsbioscience
市场价：
¥4300.00
美元价：
2580.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:581.5Da
CASRegistry#:548472-68-0
Formula:C30H30Cl2N4O4
Description:
Cis-imidazolineanalogthatinhibitstheinteractionbetweenp53anditsnegativeregulatorMDM2(IC50=0.09μM).Itinducestheexpressionofp53-regulatedgenesandexhibitspotentantiproliferativeactivityincellswithfunctionalp53,butnotincellswithmutatedp53.Nutlin-3alsoinhibitsthegrowthofhumantumorxenograftsinnudemiceby90%atadoseof200mg/kg.
Synonym(s):
(±)–4–[4,5–Bis(4–chlorophenyl)–2–(2–isopropoxy–4–methoxy–phenyl)–4,5–dihydro–imidazole–1–carbonyl]–piperazin–2–one
Purity:
>98%byTLC.
Solubility:
SolubleinDMSO(50mg/ml)
Format:
Whitecrystallinesolid
Application(s):
UsefulasanMDM2antagoNIST,asap53activatorandasanapoptosisinducer.
Reference(s):
1.VassilevL.T.etal.Invivoactivationofthep53pathwaybysmall-moleculeantagonistsofMDM2.Science2004.303(5659):844.
Warning(s):
Protectfromlight.Protectfrommoisture.Avoidfreeze/thawcycles.
ScientificCategory:
Protease
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
