Bpsbioscience/KW-2478/27758-2/50 mg
商品编号：
27758-2
品牌：
bpsbioscience
市场价：
¥14200.00
美元价：
8520.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 574.7 Da
CAS Registry #: 819812-04-9
Formula: C30H42N2O9
Target: HSP90
Background:
Heat shock protein 90 (Hsp90) is a promising target for anti-tumor therapy. KW-2478 enhanced bortezomib-induced cell growth inhibition, and exhibited enhanced anti-tumor activity against human myeloma.
Description:
KW-2478 is a novel and potent nonansamycin inhibitor of heat shock protein 90 (IC50 = 3.8 nM) designed to overcome the limitations, including low water solubility and hepatotoxicity, of 17-allylamino-17-demethoxygeldanamycin (17-AAG). KW-2478 exerts a strong antitumor activity against multiple myeloma (MM) cells with various chromosormal translocations. KW-2478 inhibits cell growth and apoptosis associated with Hsp90 client protein degradation. Recent study results have revealed that KW-2478 is able to deplete Hsp90 client Cdk9 and the phosphorylated 4E-BP1, a transcriptional kinase and a transcription inhibitor respectively, leading to reduced expression of FGFR3, c-Maf and cyclin D1.
Synonym(s):
KW 2478; KW2478
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Nakashima T, et al. Clin Cancer Res. 2010; 16(10): 2792-802.
2. Ishii, T., et al. Blood Cancer J. 2012 Apr;2(4):e68.
2. Ishii, T., et al. Blood Cancer J. 2012 Apr;2(4):e68.
Scientific Category:
HSP Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
