Bpsbioscience/KW-2478/27758-1/10 mg
商品编号：
27758-1
品牌：
bpsbioscience
市场价：
¥6900.00
美元价：
4140.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:574.7Da
CASRegistry#:819812-04-9
Formula:C30H42N2O9
Target:HSP90
Background:
Heatshockprotein90(Hsp90)isapromisingtargetforanti-tumortherapy.KW-2478enhancedbortezomib-inducedcellgrowthinhibition,andexhibitedenhancedanti-tumoractivityagainsthumanmyeloma.
Description:
KW-2478isanovelandpotentnonansamycininhibitorofheatshockprotein90(IC50=3.8nM)designedtoovercomethelimitations,includinglowwatersolubilityandhepatotoxicity,of17-allylamino-17-demethoxygeldanamycin(17-AAG).KW-2478exertsastrongantitumoractivityagainstmultiplemyeloma(MM)cellswithvariouschromosormaltranslocations.KW-2478inhibitscellgrowthandapoptosisassociatedwithHsp90clientproteindegradation.RecentstudyresultshaverevealedthatKW-2478isabletodepleteHsp90clientCdk9andthephosphorylated4E-BP1,atranscriptionalkinaseandatranscriptioninhibitorrespectively,leADIngtoreducedexpressionofFGFR3,c-MafandcyclinD1.
Synonym(s):
KW2478;KW2478
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.NakashimaT,etal.ClinCancerRes.2010;16(10):2792-802.
2.Ishii,T.,etal.BloodCancerJ.2012Apr;2(4):e68.
2.Ishii,T.,etal.BloodCancerJ.2012Apr;2(4):e68.
ScientificCategory:
HSPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
