Bpsbioscience/UPF 1069/27665-1/10 mg
商品编号：
27665-1
品牌：
bpsbioscience
市场价：
¥3100.00
美元价：
1860.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 279.3 Da
CAS Registry #: 1048371-03-4
Formula: C17H13NO3
Target: PARP2
Description:
UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.
Synonym(s):
5-phenacyloxy-2H-isoquinolin-1-one
Purity:
≥98% by HPLC
Biological Activity:
UPF 1069 is a selective inhibitor of PARP2 with IC50 of 0.3 µM. It is ~27-fold selective for PARP2 vs. PARP1 (IC50 = 8 µM).
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Moroni F, et al. Br J Pharmacol. 2009;157(5):854-862
Scientific Category:
PARP Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
