Bpsbioscience/Tankyrase Inhibitors (TNKS) 49/27659/100 mg
商品编号：
27659
品牌：
bpsbioscience
市场价：
¥29900.00
美元价：
17940.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:448.54Da
Formula:C24H24N4O3S
Background:
Tankyrase1andtankyrase2aremembersofPARPfamily.TheycanuseNAD+assubstratestotransferADP-ribosepolymersontotargetproteins.ThetankyrasesbindandPARSylateaxinproteinswhicharethenegativeregulatorofWntpathway.Thustankyrasesarepromisingtargetsfortreatmentforadenomatouspolyposiscoli.Tankyraseinhibitor49isanoptimizationoftheprevioushitcompoundinhibitor8withimprovedpotencyandselectivity.Ithasexcellenteffectsinbothtankyraseassayandcellularassay(totalβ-catenindegradationassayinSW480cells)withIC50valuesof0.1nMand1.9nM,respectively.Inaddition,itisfoundtobeadualbinderwithboththenicotinamidepocketandtheinducedpocketoftheenzymes.Intheinvivostudiesinrodents,tankyraseinhibitor49isfoundtopotentlyinhibitTNKS2autoparsylationwithIC50=7.6nM.ItalsocausesstABIlizationandaccumulationofaxinproteininSW480cellswithEC50=4nM.InDLD-1cellswithtruncatedAPC,theinhibitorinhibitstheSTFreportertranscriptionwithIC50=0.3nM,suggestingitsdownstreaminhibitoryactivityonWnt-associatedtranscription.
Description:
TankyraseInhibitor49(TNKSi49)isapotent,selectiveandorallybioavailableinhibitoroftankyrasewithIC50valueof0.1nM.
Synonym(s):
N-((1r,4r)-4-(4-cyanophenoxy)cyclohexyl)-3-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)propanamide
Purity:
≥98%byHPLC
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
HuaZ,etal.J.Med.Chem.2013,56(24):10003-10015.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
