Bpsbioscience/Rucaparib (AG-014699,PF-01367338)/27647-1/5 mg
商品编号：
27647-1
品牌：
bpsbioscience
市场价：
¥2800.00
美元价：
1680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:421.4Da
CASRegistry#:459868-92-9
Formula:C19H18FN3O•H3PO4
Target:PARP1
Background:
Rucaparib,alsonamedasAG-014699orPF-01367338,isapoly(ADPribose)polymerase(PARP)inhibitor.PARPisaDNAdamage-activatednuclearenzymethathasakeysignalingroleinthebaseexcisionrepairpathway.So,rucaparibhasbeenalsofoundtobemosteffectiveincellsdeficientinDNArepair,wherethecellsdeficientarecausedbyexposuretogenotoxicagents,suchasirrADIationproducesDNAdamageanditstoxicityisaugmentedwhentheDNArepairisimpaired.IncreasedradiosensitivityinpresenceofrucaparibwasassociatedwithpersistentDNAbreaksasdeterminedbygamma-H2AXandp53BP1foci.Rucaparibradiosensitizesprostatecancercells,mosteffectivelythosethatarePTEN-deficientandareexpressingETSgenefusionproteins,whichinhibitsNHEJDNArepair.
Description:
Rucaparib,alsoknownasAG-014699orPF-01367338,isaninhibitorofPARP1withKiof1.4nM.
Synonym(s):
Rucaparibphosphate;AG-14699;AG014699;PF-01367338;8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Chatterjee,P.,etal.CancerResearch.2012.72:B27.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
