Bpsbioscience/JW55/27633-1/10毫克
商品编号：
27633-1
品牌：
bpsbioscience
市场价：
¥3700.00
美元价：
2220.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 434.5 Da
CAS Registry #: 664993-53-7
Formula: C25H26N2O5
Target: TNKS1, TNKS2
Background:
Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
Description:
Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway
Synonym(s):
N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
Purity:
≥98% by HPLC
Biological Activity:
JW55 decreased auto-PARsylation of TNKS1 and TNKS2 in vitro with IC50 values of 1.9 µM and 830 nM respectively.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Reference(s):
Waaler, J. et al. (2012). Cancer Res. 72 2822-32.
Scientific Category:
PARP Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
