Bpsbioscience/JW 55/27633-2/50 mg
商品编号：
27633-2
品牌：
bpsbioscience
市场价：
¥7600.00
美元价：
4560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:434.5Da
CASRegistry#:664993-53-7
Formula:C25H26N2O5
Target:TNKS1,TNKS2
Background:
InhibitorofthePARPdomainoftankyrase1and2(TNKS1/2).ActivityresultsinstABIlizationofAxin2andincreaseddegradationofβ-catenin;inhibitstheβ-cateninsignalingpathway.AlsoshowntodecreasecanonicalWntsignalinginSW480andHCT-15coloncarcinomacelllines;reducescellcycleprogressionandproliferationinSW480cellsinvitro.
Description:
Cell-permeable,reversIBLetankyrase1(PARP5a)andtankyrase2(PARP5b)inhibitor.Alsoinhibitstheβ-cateninmediatedcanonicalWntpathway
Synonym(s):
N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
Purity:
≥98%byHPLC
BIOLOGicalActivity:
JW55decreasedauto-PARsylationofTNKS1andTNKS2invitrowithIC50valuesof1.9µMand830nMrespectively.
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow+4°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.
Reference(s):
Waaler,J.etal.(2012).CancerRes.722822-32.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
