Iniparib,alsoknownasBSI-201,isapotentinhibitorofpoly(ADP-ribose)polymerase-1(PARP1).PARP1playsanimportantroleintherepairofDNAdamageincellsthatoccursnaturallyorthatisinducedbyDNA-damagingchemotherapy.Iniparibexhibitssignificantantitumoractivityinvitroandinvivo,eitheraloneorincombinationwithchemotherapyinpreclinicalstudies.
≥99%
SolubleinDMSOat200mg/ml;solubleinethanolat12mg/mlwithwarming;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout10-20µM;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility.
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
1.Liang,H.andTan,A.R.IDrugs13:646-656(2010).
2.Mendeleyev,J.,etal.Biochem.Pharmacol.50:705-714(1995).
