Bpsbioscience/BMN-673 8R,9S/27610-1/10 mg
商品编号：
27610-1
品牌：
bpsbioscience
市场价：
¥6600.00
美元价：
3960.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:380.4Da
CASRegistry#:1207456-00-5
Formula:C19H14F2N6O
Target:PARP1
Background:
BMN-673isanorallybioavailableinhibitorofthenuclearenzymepoly(ADP-ribose)polymerase(PARP)withpotentialantineoplasticactivity.PARPinhibitorBMN-673selectivelybindstoPARPandpreventsPARP-mediatedDNArepairofsinglestrandDNAbreaksviathebase-excisionrepairpathway.ThisenhancestheaccumulationofDNAstrandbreaks,promotesgenomicinstABIlityandeventuallyleadstoapoptosis.PARPcatalyzespost-translationalADP-ribosylationofnuclearproteinsthatsignalandrecruitotherproteinstorepairdamagedDNAandisactivatedbysingle-strandDNAbreaks.BMN-673hasbeenproventobehighlyactiveinmousemodelsofhumancancerandalsoappearstobemoreselectivelycytotoxicwithalongerhalf-lifeandbetterbioavailabilityascomparedtoothercompoundsindevelopment.
Description:
BMN673isanovelPARPinhibitorwithIC50of0.58nM(PARP1).ItdoesnotinhibitPARGandishighlysensitivetoPTENmutation.BMN-673(8R,9S)isthe(8R,9S)enantiomerofBMN-673.
Synonym(s):
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.ShenY,etal.ClinCancerRes2013;19:5003-5015.
2.CardnellRJ,etal.ClinCancerRes2014;20:2237.
3.MuraiJ,etal.MolCancerTher2014;13:433-443.
4.CardnellRJ,etal.ClinCancerRes2013;19:6322-6328.
2.CardnellRJ,etal.ClinCancerRes2014;20:2237.
3.MuraiJ,etal.MolCancerTher2014;13:433-443.
4.CardnellRJ,etal.ClinCancerRes2013;19:6322-6328.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
