Bpsbioscience/BMN 673/27609-1/10 mg
商品编号：
27609-1
品牌：
bpsbioscience
市场价：
¥7900.00
美元价：
4740.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:380.4Da
CASRegistry#:1207456-01-6
Formula:C19H14F2N6O
Target:PARP1
Background:
BMN673hasshownanti-tumoractivitybothinvitroandinvivo.Itinhibitedproliferationoftumorcellsandxenograftswithdefectsinhomologousrecombination.ThecombinationofBMN673andDNA-damagingagentsdemonstratedsynergisticanti-tumoreffects.Inaddition,studyshowedthattheexpressionlevelsofDNArepairproteinsandstatusofPI3KpathwaypredictresponsetoBMN673insmallcelllungcancer.BMN673iscurrentlyunderinvestigationinmultipleclinicaltrialsforadvancedsolidtumorsorhematologicalmalignancies,eitherasmonotherapyorincombinationwithotheranti-tumoragents.
Description:
BMN673isapotentandselectivePARP1/2inhibitorwithKiof1.2and0.9nM,respectively.
Synonym(s):
(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-1H-pyrido[4,3,2-de]phthalazin-3(2H)-one
Purity:
≥98%byHPLC
BIOLOGicalActivity:
BMN673showedIC50valueof0.57nMinenzymaticassayofPARP11.Ininvitroassay,itexhibitedgreaterpotencythanotherexistingPARPinhibitors,suchasveliparib,rucaparib,andolaparib.ItismuchmorepotentattrappingPARP-DNAcomplexesthanotherPARPinhibitors.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.ShenY,etal.ClinCancerRes2013;19:5003-5015.
2.CardnellRJ,etal.ClinCancerRes2014;20:2237.
3.MuraiJ,etal.MolCancerTher2014;13:433-443.
4.CardnellRJ,etal.ClinCancerRes2013;19:6322-6328.
2.CardnellRJ,etal.ClinCancerRes2014;20:2237.
3.MuraiJ,etal.MolCancerTher2014;13:433-443.
4.CardnellRJ,etal.ClinCancerRes2013;19:6322-6328.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
