Bpsbioscience/AG-14361/27602-2/10 mg
商品编号：
27602-2
品牌：
bpsbioscience
市场价：
¥6300.00
美元价：
3780.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:320.4Da
CASRegistry#:328543-09-5
Formula:C19H20N4O
Target:PARP1
Background:
A17-hourexposureofA549cellsto0.4µMAG14361doesnotchangetheexpressionofthe6800genes.Thus,although0.4µMAG14361inhibitscellularPARP-1activitybymorethan85%,itessentiallydoesnotchangegeneexpressionandcellproliferation,indicatingthatthecellulareffectsofthislowconcentrationofAG14361arespecificforPARP-1inhibition.Higher,growth-inhibitoryconcentrationsofAG14361affectsgeneexpression,buttheseeffectsarenotlikelytoberelatedtoPARP-1inhibitionbecausecellproliferationisaffectedequallyinPARP-/-andPARP-1+/+cells.
Description:
AG14361isapotentinhibitorofPARP1withKiof<5nM.Itisatleast1000-foldmorepotentthanthebenzamides.AG14361treatmentbeforeirrADIationstatisticallysignificantlyincreasesthesensitivitytoradiationtherapy.AG14361enhancesthegrowth-inhibitoryandcytotoxiceffectsoftopoisomeraseIpoisonsandincreasesthepersistenceofcamptothecin-inducedDNAsingle-strandbreaks.
Synonym(s):
1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO.Solubilityinwaterorethanolis<1mg/ml
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.SmithLM,etal.ClinCancerRes.2005Dec1;11(23):8449-57.
2.CurtinNJ,etal.ClinCancerRes.2004Feb1;10(3):881-9.
3.CalabreseCR,etal.JNatlCancerInst.2004Jan7;96(1):56-67.
2.CurtinNJ,etal.ClinCancerRes.2004Feb1;10(3):881-9.
3.CalabreseCR,etal.JNatlCancerInst.2004Jan7;96(1):56-67.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
