Bpsbioscience/PF-2545920/27637-1/5毫克
商品编号：
27637-1
品牌：
bpsbioscience
市场价：
¥5200.00
美元价：
3120.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:392.45Da
CASRegistry#:1292799-56-4
Formula:C25H20N4O
Target:PDE10A
Background:
PDE10AishighlyexpressedinthemediumspinyneuronsofthestriatumandregulatesbothcGMPandcAMP.ThePDE10Ainhibitorsarebelievedtoregulatecyclicnucleotidesignalinginthecortices-triatothalamiccircuit.PreviousinhibitorsofPDEhavepotentialtherapeuticutilitybutalsohavepotentialsafetyrisksduetooff-targetPDEinhibition.TherebyPF-2545920isdevelopedasamoreselectiveinhibitor.PF-2545920isshowntobeefficaciousbothinvitroandinvivowithimprovedpenetrationinCNS.IthasexcellentinvivoefficacyinneuRochemicalelevationofcyclicnucleotidesandinmodelspredictiveofantipsychoticactivity.AdmiNISTrationofPF-2545920tomicecancauseincreaseinstriatalcGMP
Description:
PF-2545920isaninhibitorofphosphodiesterase10A(PDE10A)withIC50valueof0.37nM
Synonym(s):
2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
VerhoestPR,etal.J.Med.Chem.2009Aug27;52(16):5188-96.
ScientificCategory:
PDEInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
