1.Hung,S.H.,etal.,J.Biol.Chem.281(39),29236-29244(2006).
2.Hambleton,R.,etal.,J.Biol.Chem.280(47),39168-39174(2005).
ApplicationReference(s):
1. DiscoveryofaNovelSeriesofPyrazolo[1,5-a]pyrimidine-BasedPhosphodiesterase2AInhibitorsStructurallyDifferentfromN-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide(TAK-915),fortheTreatmentofCognitiveDisorders(2017)
2. Geneticdeletionandpharmacologicalinhibitionofphosphodiesterase10Aprotectsmicefromdiet-inducedobesityandinsulinresistance(2014)
3.AnalysisofsubstratespecificityandkineticsofcyclicnucleotidephosphodiesteraseswithN"-methylanthraniloyl-substitutedpurineandpyrimidine3",5"-cyclicnucleotidesbyfluorescencespectrometry(2013)
4.Thenovelphosphodiesterase10AinhibitorTHPP-1hasantipsychotic-likeeffectsinratandimprovescognitioninratandrhesusmonkey(2013)
