1.Nagel,D.J.,etal.,Circ.Res.98(6),777-784(2006).
2.Goraya,T.A..,etal.,J.Biol.Chem.279(39),40494-40504(2004).
ApplicationReference(s):
1. PDE1AinhibitionelicitscGMP-dependentrelaxationofratmesentericarteries(2017)
2. DiscoveryofaNovelSeriesofPyrazolo[1,5-a]pyrimidine-BasedPhosphodiesterase2AInhibitorsStructurallyDifferentfromN-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide(TAK-915),fortheTreatmentofCognitiveDisorders (2017)
3.CharacterizationofthebindingpropertiesofT-773asaPETrADIoligandforphosphodiesterase10A(2015)
4.Geneticdeletionandpharmacologicalinhibitionofphosphodiesterase10Aprotectsmicefromdiet-inducedobesityandinsulinresistance(2014)
5.Thenovelphosphodiesterase10AinhibitorTHPP-1hasantipsychotic-likeeffectsinratandimprovescognitioninratandrhesusmonkey(2013)