Bpsbioscience/Tau-441(S199E)蛋白/90324/20μg
商品编号:
90324
品牌:
bpsbioscience
市场价:
¥5200.00
美元价:
3120.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:64kDa
Genbank#:P10636-8
Tag(s):NoTag
a.a:fulllength
Background:
Tau-441orTau-FisamemberoftheTaufamilyofproteinswhichfunctiontostABIlizethemicrotubulesbybindingtothem.TauproteinsaresubjecttophosphorylationandthisphenomenonregulatestheassociationoftheTauproteinwiththemicrotubules(1).DepositsofAlzheimer"sdiseaseAD-associatedproteins,suchashyperphosphorylatedTau,aswellasothersharedmisfoldedproteins,suchas,β-amyloidprecursorprotein(βAPP),ubiquitin,andvariouschaperonesandproteinkinasesarethoughttoplayapathologicroleinthecognitivedeclineandmuscularfailure.MalfunctioningofTauproteinsisassociatedwithmicrotubulesdisintegrationandcollapsingoftheneuronaltransportsystem(2).
Description:
HumanTau-441withaS199Emutation,GenBankAccessionNo.P10636-8,fulllength,expressedinanE.coliexpressionsystem.MW=64kDa.
Synonym(s):
Tau-F,(N2R4),Tau-4,MAPT,MSTD;PPND;DDPAC;MAPTL;MTBT1;MTBT2;FTDP-17;FLJ31424;MGC138549
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMPMSF,25%glycerol.
Storage/Stability:
Storeproductat–80°C.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugationandstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles.
Application(s):
KinaseAssay,WesternBlot
Reference(s):
1.Zilka,N.,etal.TruncatedtaufromsporADIcAlzheimer"sdiseasesufficestodriveneurofibrillarydegenerationinvivo.FEBSLett.2006;508:3582-3588.
2.Rial,A.etal:CalciumDyshomeostasisin-AmyloidandTau-bearingSkeletalMyotubes.J.Biol.Chem.,2004;279:3524-53532.
ScientificCategory:
Neuroscience
ProductType:
Protein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。