Bpsbioscience/EPZ5676/27625-2/50毫克
商品编号：
27625-2
品牌：
bpsbioscience
市场价：
¥14200.00
美元价：
8520.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:562.7Da
CASRegistry#:1380288-87-8
Formula:C30H42N8O3
Target:Dot1L
Background:
EPZ5676isapotentinhibitorofDOT1Lhistonemethyltransferasethat,accordingtoX-raycrystallographicanalysis,occupiestheS-adenosylmethionine(SAM)bindingpocketofDOT1LandinducesconformationalchangesinDOT1LresultingintheopeningofahydrophobicpocketbeyondtheaminoacidportionofSAM.EPZ5676hasbeeninvestigatedforthetreatmentofMLL-rearrangedleukemiainmultiplestudieswhereresultshaveshownthatEPZ5676inhibitsH3K79methylationandtheexpressionofMLL-fusiontargetgeneandpotentlykillsacuteleukemiacelllinesbearingMLLtranslocation.
Description:
EPZ-5676isanS-adenosylmethionine(SAM)competitiveinhibitorofproteinmethyltransferaseDOT1LwithKiof80pM.
Synonym(s):
(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol
Purity:
≥98%byHPLC
BIOLOGicalActivity:
EPZ5676selectivelyinhibitsDOTILwithanIC50of0.8nM,whichis37000-foldgreaterinselectivityvs.othermethyltransferases,includingCARM1,EHMT1/2,EZH1/2,PRMT1/2/5/6/8,SETD7,SMYD2/3,andWHSC1/1L1.InhibitsH3K79methylationintumors.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
DaigleSR,etal.Blood.2013Aug8;122(6):1017-1025.
ScientificCategory:
MethyltransferaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
