Bpsbioscience/EPZ005687/27624-2/25 mg
商品编号：
27624-2
品牌：
bpsbioscience
市场价：
¥5800.00
美元价：
3480.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:539.7Da
CASRegistry#:1396772-26-1
Formula:C32H37N5O3
Target:EZH2
Background:
EPZ005687isapotentinhibitorofEZH2,anenzymaticsubunitofpolycombrepressivecomplex2(PRC2)catalyzingthemethylationofhistoneH3lysine27(H3K27),thatinhibitsEZH2withKiof24nM,whichis500-foldand50-foldgreaterinselectivitythan15otherproteinmethyltransferasesandcloselyrelatedEZH1respectively.EPZ005687concentration-dependentlyinhibitstheenzymaticactivityofPRC2withIC50of54nMthroughbindingtotheS-adenosylmethionine(SAM)pocketoftheEZH2SETdomain.StudyresultshaveshownthatEPZ005687reducesH3K27methylationinavarietyoflymphomacellsandinducesapoptoticcellkillinginheterozygousTyr641orAla677mutantcells.
Description:
EPZ-005687isapotentandselectiveinhibitorofEZH2.
Synonym(s):
EPZ005687;EPZ-005687;1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]indazole-4-carboxamide
Purity:
≥98%byHPLC
BIOLOGicalActivity:
PotentandselectiveEZH2inhibitorwithKiof24nM.Itexhibits50-foldselectivityagainstEZH1and500-foldselectivityagainst15otherproteinmethyltransferases.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
KnutsonSK,etal.NatChemBiol.2012Nov;8(11):890-6.
ScientificCategory:
Methyltransferaseinhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
