Bpsbioscience/EPZ-6438/27626-2/50毫克
商品编号：
27626-2
品牌：
bpsbioscience
市场价：
¥5600.00
美元价：
3360.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:572.7Da
CASRegistry#:1403254-99-8
Formula:C34H44N4O4
Target:EZH2
Background:
EPZ-6438competitivelybindstotheS-adenosylmethionine(SAM)bindingsiteofEZH2andalsonon-competitivelybindstothebindingsitesofpeptideornucleosomesubstrate.EPZ-6438selectivelyinhibitsEZH2withselectivity35-foldgreaterthanEZH1.StudyresultshavesuggestedthatEPZ-6438exhibitsdramaticandpermanentanti-tumoractivityinMRTmodelsthroughsynergisticeffectsofEPZ-6438-mediatedEZH2inhibitiononseveralcancerpathways.
Description:
EPZ-6438isapotentandbio-availableinhibitorofEZH2,thecatalyticsubunitofpolycombrepressivecomplex2(PRC2)catalyzingthemethylationoflysine27ofhistoneH3(H3K27),thatinhibitstheactivityofhumanPRC2-containingwild-typeEZH2(Ki=2.5nM).
Synonym(s):
E-7438;N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide
Purity:
≥99%byHPLC
BIOLOGicalActivity:
EPZ-6438isapotent,andselectiveEZH2inhibitorwithKiandIC50of2.5nMand11nM,exhibitinga35-foldselectivityversusEZH1andover4,500-foldselectivityrelativeto14otherHMTs.
Solubility:
SolubleinEtOH
Storage/StABIlity:
Storedesiccatedatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Knutson,SK,etal.PNAS2013;110(19):7922-7927.
Warning(s):
Protectfrommoisture.
ScientificCategory:
MethyltransferaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
