Bpsbioscience/3-去甲扎诺霉素A（DZNep）盐酸盐/27618-1/5 mg
商品编号：
27618-1
品牌：
bpsbioscience
市场价：
¥9000.00
美元价：
5400.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 298.7 Da
CAS Registry #: 120964-45-6
Formula: C12H14N4O3 • HCl
Target: EZH2
Background:
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2. Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. Induces apoptotic cell death in cancer cells and inhibits s-adenosylhomocysteine (SAH) hydrolase. Decreases global DNA methylation and enhances Oct 4 expression in chemically induced pluripotent stem cells (CiPSCs). DZNeP decreased cell migration, which was additionally reduced by DZNeP/gemcitabine combination.
Description:
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.
Synonym(s):
NSC 617989 hydrochloride; DZNep; 3-Deazaneplanocin A; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;hydrochloride
Purity:
≥98% by HPLC
Biological Activity:
3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM. DZNep treatment resulted in dose-dependent inhibition of proliferation in NSCLC cell lines with IC50 ranging from 0.08 to 0.24 µM.
Solubility:
Soluble in Water
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Fujiwara T, et al. J Biol Chem. 2014 Mar 21;289(12):8121-34.
2. Cui, B., et al. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70.
3. Cheng, L.L., et al. Clin Cancer Res. 2012 Aug 1;18(15):4201-12.
4. Nakagawa, S., et al. Oncol Rep. 2014 Feb;31(2):983-8.
2. Cui, B., et al. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70.
3. Cheng, L.L., et al. Clin Cancer Res. 2012 Aug 1;18(15):4201-12.
4. Nakagawa, S., et al. Oncol Rep. 2014 Feb;31(2):983-8.
Scientific Category:
Methyltransferase inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
