Bpsbioscience/3-Deazaneplanocin (DZNep)/27617-1/5 mg
商品编号：
27617-1
品牌：
bpsbioscience
市场价：
¥9000.00
美元价：
5400.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:262.3Da
CASRegistry#:102052-95-9
Formula:C12H24N4O3
Target:EZH2
Background:
3-DeazaneplanocinA(DZNep)isanS-AdenosylhomocysteineHydrolaseinhibitorandhistonemethyltransferaseEZH2inhibitor.ItswitchesonrepressedtumorsuppressorgenesandinducesapoptosisbyinhibitingtheexpressionofEZH2.BlocksEZH2activityandtrimethylationoflysine27onhistoneH3invitro.Inducesapoptoticcelldeathincancercellsandinhibitss-adenosylhomocysteine(SAH)hydrolase.DecreasesglobalDNAmethylationandenhancesOct4expressioninchemicallyinducedpluripotentstemcells(CiPSCs).DZNePdecreasedcellmigration,whichwasadditionallyreducedbyDZNeP/gemcitABInecombination.
Description:
Cell-permeableinhibitorofthehistonemethyltransferaseEZH2.
Synonym(s):
DZNep;3-DeazaneplanocinA;NSC617989;NSC617989;(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Purity:
≥98%byHPLC
BIOLOGicalActivity:
3-deazaneplanocinA(DZNeP),ananalogofadenosine,isacompetitiveinhibitorofS-adenosylhomocysteinehydrolasewithKiof50pM.DZNeptreatmentresultedindose-dependentinhibitionofproliferationinNSCLCcelllineswithIC50rangingfrom0.08to0.24µM.
Solubility:
SolubleinWater
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.FujiwaraT,etal.JBiolChem.2014Mar21;289(12):8121-34.
2.Cui,B.,etal.JClinEndocrinolMetab.2014Jun;99(6):E962-70.
3.Cheng,L.L.,etal.ClinCancerRes.2012Aug1;18(15):4201-12.
4.Nakagawa,S.,etal.OncolRep.2014Feb;31(2):983-8.
2.Cui,B.,etal.JClinEndocrinolMetab.2014Jun;99(6):E962-70.
3.Cheng,L.L.,etal.ClinCancerRes.2012Aug1;18(15):4201-12.
4.Nakagawa,S.,etal.OncolRep.2014Feb;31(2):983-8.
ScientificCategory:
Methyltransferaseinhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
