Bpsbioscience/XL-888/27781-3/25 mg
商品编号：
27781-3
品牌：
bpsbioscience
市场价：
¥11200.00
美元价：
6720.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:503.6Da
CASRegistry#:1149705-71-4
Formula:C29H37N5O3
Target:HSP90
Background:
X-raycrystallographicanalysisrevealsthattheXL-888bindstoHSP90throughtheformationofH-bondingbetweentheN-(R)-sec-butylanthranilamidemoietyofXL-888andASP93ofHSP90.
Description:
XL-888isanovelandorally-bioavailableinhibitorofheatshockprotein90(HSP90)thatselectivelyinhibitsHSP90αandHSP90βwithIC50sof22nMand44nMrespectively.ItalsoexertsconsiderablyweakerinhibitionagainstarangeofotherdiversekinaseswithIC50morethan3600nMforall.Inrecentstudies,XL-888hasexhibitsstronganti-proliferativeactivitiesinapaneloftumorcellswithvaluesofIC50rangingfrom0.1nMto45.5nM.
Synonym(s):
Xl888;Xl888;2-(butan-2-ylamino)-4-N-[(1R,5S)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azABIcyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.ParaisoKH,etal.ClinCancerRes.2012;18(9):2502-2514.
2.BusseniusJ,etal.BioorgMedChemLett.2012;22(17):5396-5404.
2.BusseniusJ,etal.BioorgMedChemLett.2012;22(17):5396-5404.
ScientificCategory:
HSPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
