Bpsbioscience/VER 155008/27777-1/10 mg
商品编号：
27777-1
品牌：
bpsbioscience
市场价：
¥7300.00
美元价：
4380.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:556.4Da
CASRegistry#:1134156-31-2
Formula:C25H23Cl2N7O4
Target:HSP70
Background:
VER155008isapotentinhibitorofheatshockprotein70(Hsp70)familyofchaperones,whichhavebeenshowntocontributetocancercellsurvivalviaanti-apoptoticfunctions,thatinhibitsHsp70(IC50=0.5µM)aswellasheatshockcognate71kDaprotein(Hsc70)and78kDaglucose-regulatedprotein(Grp78)toalesserextent.X-raycrystallographyanalysisrevealsthatVER155008bindstotheATPasepocketofHsp70leADIngtotheinhibitionoftheintrinsicATPaseactivityofHsp70.StudyresultsalsohavedemonstratedthatVER155008inducescellproliferationandapoptosisinhumancancercelllines.
Description:
VER-155002isasmallmolecule,ATP-derivativeinhibitorofHSP70(IC50=500nM).Thecompoundinhibitsproliferationofseveralcolonandbreastcancercelllines,inducescaspasedependentapoptosisinBT474cellsanddownregulatesexpressionofHer2andRaf-1inHCT116cells.
Synonym(s):
adenosine-derivedinhibitor;VER155008;VER-155008;me4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile
Solubility:
SolubleinDMSO
Format:
whitetolightbrownpowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
MasseyAJ,etal.CancerChemotherPharmacol.2010;66(3):535-545
Warning(s):
Protectfrommoisture.
ScientificCategory:
HSPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
