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当前位置: 首页 > 产品中心 > Other_kits > Bpsbioscience/IDH2(R140Q) Assay Kit/79309/96 reactions
商品详细Bpsbioscience/IDH2(R140Q) Assay Kit/79309/96 reactions
Bpsbioscience/IDH2(R140Q) Assay Kit/79309/96 reactions
Bpsbioscience/IDH2(R140Q) Assay Kit/79309/96 reactions
商品编号: 79309
品牌: bpsbioscience
市场价: ¥10700.00
美元价: 6420.00
产地: 美国(厂家直采)
公司:
产品分类: 其它检测试剂盒
公司分类: Other_kits
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Background:
Isocitratedehydrogenasesareenzymesthatcatalyzetheoxidativedecarboxylationofisocitrateto2-oxoglutarate.Mutationsinisocitratedehydrogenases1and2(IDH1andIDH2)havebeenreportedinamultitudeofhumancancers.WhilethewildtypeIDH2,producesα-ketoglutarate(α-KG)throughthereductionofNADP+toNADPH,theIDH2(R140Q)mutantcatalyzesconversionofα-ketoglutarateto2-hydroxy-glutarate(2-HG)byoxidizingNADPHtoNADP+.GenomicstudieshaveidentifiedtheIDH2(R140Q)mutationinvariouscancertypes,includingasglioma,chondrosarcoma,AMLaswellassmallpercentageofprostate,lungandcoloncancers.
Description:
TheIDH2(R140Q)AssayKitisdesignedtomeasureIDH2(R140Q)activityforscreeningandprofilingapplicationsbymeasuringNADPHconsumption.
Synonym(s):
IsocitrateDehydrogenase2,IDH2,OxalosuccinateDecarboxylase,IDHM
SuppliedAs:
TheIDH2(R140Q)AssayKitcomesinaconvenient96-wellformat,withenoughpurifiedrecombinantIDH2(R140Q)enzyme,α-KG,NADPH,NADPHdetectionreagents,andassaybufferfor100enzymereactions.
Format:

Instructionsforuse:
Seeassaykitdatasheetfordetailedprotocol.
Storage/StABIlity:
Stableatleast6monthsfromdateofreceipt,whenstoredasdirected.Kitcomponentsrequiredifferentstorageconditions.Besuretostoreeachcomponentatthepropertemperatureuponarrival.
Application(s):
UsefulforscreeningsmallmolecularinhibitorsfordrugdiscoveryandHTSapplications.
Reference(s):

Wang,F.et.al.Science340:622-626(2013).

Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
MetabolicEnzymes
ProductType:
AssayKit
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。