Bpsbioscience/CDK1/CyclinA2，GST标签/40100/10µg
商品编号：
40100
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:59kDa(CDK1),78kDa(CyclinA2)
Genbank#:NM_001786,NM_001237
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
CDK1orCellDivisionControlprotein1isessentialforthecompletionofSTART,thecontrollingeventinthecellcyclethatisrequiredtoinitiatemitosis.CDK1isacatalyticsubunitofaproteinkinasecomplex,calledtheM-PhasePromotingFactorthatinducesentryintomitosisandisuniversalamongeukaryotes(1).PhosphorylationofBcl-2inG2/Mphase-arrestedcellsfollowingphotodynamictherapywithhypericininvolvesaCDK1-mediatedsignalanddelaystheonsetofapoptosis.TherapeuticpotentialofCDKinhibitorNU2058inandrogen-independentprostatecancerhasalsobeendemonstrated(2).
Description:
ComplexofrecombinanthumanCDK1andCyclinA2,fulllength,withN-terminalGST-tags(GenBankAccessionNo.NM_001786,andNM_001237respectively),co-expressedbySf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
Cyclin-DependentKinase1,CDC2CDC28A;MGC111195;DKFZp686L20222
CyclinA2:CCN1;CCNA
CyclinA2:CCN1;CCNA
Purity:
≥70%
SpecificActivity:
205pmol/min/µg
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Vantieghem,A.etal:PhosphorylationofBcl-2inG2/Mphase-arrestedcellsfollowingphotodynamictherapywithhypericininvolvesaCDK1-mediatedsignalanddelaystheonsetofapoptosis.J.Biol.Chem.2002;277(40):37718-31.
2.Rigas,A.C.etal:TherapeuticpotentialofCDKinhibitorNU2058inandrogen-independentprostatecancer.Oncogene.2007;18.
2.Rigas,A.C.etal:TherapeuticpotentialofCDKinhibitorNU2058inandrogen-independentprostatecancer.Oncogene.2007;18.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
