Bpsbioscience/AMPK (A2/B2/G1), His-tag/40705/5 µg
商品编号：
40705
品牌：
bpsbioscience
市场价：
¥9600.00
美元价：
5760.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:~146kDa(complex)
Genbank#:NM_006252(A2),NM_005399(B2),NM_002733(G1)
Tag(s):C-terminalHis-tag
a.a:fulllength
Background:
AMP-activatedproteinkinase(AMPK)exhibitsakeyroleasamasterregulatorofcellularenergyhomeostasis(1).AMPKexistsasaheterotrimericcomplexcomposedofacatalyticαsubunitandregulatoryβandγsubunits.BindingofAMPtotheγsubunitallostericallyactivatesthecomplex.AMPKisactivatedinresponsetostressesthatdepletecellularATP(lowglucose,hypoxiaandischemia)andviasignalingpathwaysinresponsetoADIponectin,leptinandCAMKKβ(2).
Description:
RecombinanthumanAMPK(combinationofA2/B2/G1subunits),fulllength,withC-terminalHis-tags,expressedinSf9insectcellsviaabaculovirusexpressionsystem.MW=69kDa(A2),36kDa(B2),41kDa(G1).
Synonym(s):
SubunitA2:PRKAA2,AMPK,AMPK2,PRKAA
SubunitB2:PRKAB2,MGC61468
SubunitG1:PRKAG1,AMPKG,MGC8666
SubunitB2:PRKAB2,MGC61468
SubunitG1:PRKAG1,AMPKG,MGC8666
Purity:
≥75%
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Hardie,G.D.TheAMP-activatedproteinkinasepathway–newplayersupstreamanddownstream.J.CellSci.2004;117:5479–5487.
2.Kahn,B.B.etal.AMP-activatedproteinkinase:Ancientenergygaugeprovidescluestomodernunderstandingofmetabolism.CellMetab;2005:1,15–25.
2.Kahn,B.B.etal.AMP-activatedproteinkinase:Ancientenergygaugeprovidescluestomodernunderstandingofmetabolism.CellMetab;2005:1,15–25.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
