Bpsbioscience/AMPK (A2/ B1/G1), His-tag/40704/5 µg
商品编号：
40704
品牌：
bpsbioscience
市场价：
¥9600.00
美元价：
5760.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:~148kDa(complex)
Genbank#:NM_006252(A2),NM_006253(B1),NM_002733(G1)
Tag(s):C-terminalHis-tag
a.a:fulllength
Background:
AMPK(A2/B1/G1)playsakeyroleininsulinsignalingpathwayandisamajortherapeutictargetforthetreatmentofdiabetes(1).AMPKisviewedasafuelsensorforglucoseandlipidmetabolismbymodulatingtheactivityoftheautonomousnervoussysteminvivo.Short-termoverexpressionofaconstitutivelyactiveformofAMPKintheliverleadstomildhypoglycemiaandfattyliverduetoincreasedfattyacidutilization(2).
Description:
RecombinanthumanAMPK(combinationofA2/B1/G1subunits),fulllength,withC-terminalHis-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
SubunitA2:PRKAA2,AMPK,AMPK2,PRKAA
SubunitB1:PRKAB1,AMPK,HAMPKb,MGC17785
SubunitG1:PRKAG1,AMPKG,MGC8666
SubunitB1:PRKAB1,AMPK,HAMPKb,MGC17785
SubunitG1:PRKAG1,AMPKG,MGC8666
Purity:
≥75%
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Viollet,B.etal:PhysiologicalroleofAMP-activatedproteinkinase(AMPK):insightsfromknockoutmousemodels.Biochem.Soc.Trans.2003;31;216–219.
2.Foretz,M.etal:Short-termoverexpressionofaconstitutivelyactiveformofAMP-activatedproteinkinaseintheliverleadstomildhypoglycemiaandfattyliver.Diabetes,2005;54(5);1331-1339.
2.Foretz,M.etal:Short-termoverexpressionofaconstitutivelyactiveformofAMP-activatedproteinkinaseintheliverleadstomildhypoglycemiaandfattyliver.Diabetes,2005;54(5);1331-1339.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
