Bpsbioscience/GSK256066/27751-1/10 mg
商品编号：
27751-1
品牌：
bpsbioscience
市场价：
¥6800.00
美元价：
4080.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 518.6 Da
CAS Registry #: 801312-28-7
Formula: C27H26N4O5S
Target: PDE4
Description:
GSK256066 is a selective PDE4 inhibitor with an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 vs. other PDE isoforms. Often used clinically by inhalation in chronic obstructive pulmonary disease and asthma.
Synonym(s):
6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
Biological Activity:
IC50 =3.2 pM for PDE4B, with >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. GSK256066 inhibits PDE4 isoforms A-D with equal affinity.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther, 2011, 337(1), 145-154.
2. Woodrow MD, et al. Bioorg Med Chem Lett, 2009, 19(17), 5261-5265.
2. Woodrow MD, et al. Bioorg Med Chem Lett, 2009, 19(17), 5261-5265.
Scientific Category:
PDE Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
