Bpsbioscience/Forskolin/27067/10 mg
商品编号：
27067
品牌：
bpsbioscience
市场价：
¥2900.00
美元价：
1740.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 410.5 Da
Genbank #: 439081-18-2
Formula: C22H34O7
Description:
Forskolin is a cell permeable adenylate cyclase activator which causes an increase in the intracellular concentration of cAMP. This makes it an important hypotensive and vasodilatory agent. Forskolin also affects calcium currents and inhibits PKC (Protein Kinase C)-stimulated MAPK and RAF-1.
Purity:
≥95% by HPLC
Biological Activity:
Forskolin is shown to activate adenylate cyclase at EC50 of 5-10 µM. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP.
Solubility:
Soluble in DMSO at 160 mg/ml; very poorly soluble in water; maximum solubility in water is estimated to be about 25-50 µM. Buffers, serum, or other additives may increase or decrease the aqueous solubility. Forskolin is also soluble in ethanol (50 mg/ml), but this solvent is not recommended, as it inhibits forskolin activation of adenylate cyclase.
Format:
White to off-white granular powder.
Storage / Stability:
Store at or below -20°C. Stable for at least 1 year when stored as directed. Anhydrous DMSO stock solutions are stable for at least 3 months.
Application(s):
Forskolin is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations.
Reference(s):
1. Awad, et al., J.Biol.Chem 258: 2690 (1983).
2. KB Seamon., et al., PNAS 78 (6):3363 – 3367 (1981).
3. Siddhanti, S.R., et al., Endocrinology 136: 4834 – 4841 (1995).
2. KB Seamon., et al., PNAS 78 (6):3363 – 3367 (1981).
3. Siddhanti, S.R., et al., Endocrinology 136: 4834 – 4841 (1995).
Warning(s):
Protect from moisture. Avoid freeze/thaw cycles of solutions.
Scientific Category:
cAMP activator, kinase inhibitor
Product Type:
Inhibitor/Activator
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
