Bpsbioscience/Cyclopamine, Free Base/27013/10 mg
商品编号：
27013
品牌：
bpsbioscience
市场价：
¥2600.00
美元价：
1560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 411.6 Da
CAS Registry #: 4449-51-8.
Formula: C27H41NO2
Description:
Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to induce apoptosis in colorectal adenoma cell lines, carcinoma-derived cell lines, and skin basal cell carcinomas and is being investigated as an anti-cancer drug.
Purity:
≥99% by HPLC
Biological Activity:
Cyclopamine inhibits the activity for Hedgehog signaling-dependent motor neuron differentiation with IC50 = 300 nmol/L.
Solubility:
Soluble in ethanol, methanol and DMSO. Ethanol is the best solvent for biological use. To make a 2% solution, heat cyclopamine in ethanol to 50-60°C. In methanol or DMSO, solubility is 7 mg/ml and 4 mg/ml respectively.
Format:
White to off-white crystalline solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Taipale, J., et al., Nature 2000; 406: 944 – 945.
2. Chen, J.K., et al., Genes & Dev. 2002; 16: 2743 – 2748.
3. Qualtrough, D., et al., Int J Cancer. 2004; 110: 831-837.
2. Chen, J.K., et al., Genes & Dev. 2002; 16: 2743 – 2748.
3. Qualtrough, D., et al., Int J Cancer. 2004; 110: 831-837.
Scientific Category:
Hedgehog Pathway
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
