Bpsbioscience/BIIB021/27046/5 mg
商品编号：
27046
品牌：
bpsbioscience
市场价：
¥2600.00
美元价：
1560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:318.8Da
CASRegistry#:848695-25-0
Formula:C14H15ClN6O
Description:
BIIB021isanorallyavailable,syntheticsmall-moleculeHsp90inhibitor.ItbindsintheATP-bindingpocketofHsp90(Ki=1.7±0.4nM)andinducesHER-2degradationwithanEC50of38±10nMinMCF-7cells.ItncreasesexpressionoftheheatshockproteinsHsp90αandHsp70,buthasnoeffectonexpressionofthenonclientproteinphosphatidylinositol3-kinasep85subunit.BIIB021inhibitstheproliferationofN87,MCF-7,andBT474tumorcellswithIC50valuesof0.06,0.31,and0.14µM,respectively.IthassignificantantitumoractivityinN87stomach,BT474breast,CWR22prostate,U87glioblastoma,SKOV3ovarian,andPanc-1pancreatictumorxenograftmodels.
Synonym(s):
CNF2024
Purity:
≥99%
Solubility:
SolubleinDMSOat65mg/ml;solubleinethanolat3mg/mlwithwarming;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout50-100µM.
Format:
Off-whiteorlightbrownpowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Lundgren,K.,etal.Mol.CancerTher.8:921-929(2009).
ScientificCategory:
HSP90
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
