Bpsbioscience/Apremilast (CC-10004)/27735-1/5 mg
商品编号：
27735-1
品牌：
bpsbioscience
市场价：
¥5200.00
美元价：
3120.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:460.5Da
CASRegistry#:608141-41-9
Formula:C22H24N2O7S
Target:PDE4
Description:
Apremilast,alsoknownasCC-10004,isanovelandpotentsmall-moleculeinhibitorofphosphodiesterase4(PDE4),akeyenzymeinvolvedincyclicadenosinemonophosphate(cAMP)degradationandcytokineproductionofinflammatorycells.
Synonym(s):
Apremilast;CC-10004;N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
BIOLOGicalActivity:
ApremilastbindstothecatalyticsiteofPDE4,withvaluesofinhibitionconstantIC50andaffinityconstantKiof0.074µMand68nMrespectively,consequentlyleADIngtothedegradationofcAMP.Apremilastexhibitsanti-inflammatoryactivitiesagainstinflammatorydiseaseinanimalmodelsaswellashumanchronicinflammatorydiseases(suchaspsoriasisandpsoriaticarthritis)byblockingthesynthesisofarangeofpro-flammatorycytokinesandchemokines,includingtumornecrosisfactoralpha,interleukin23,CXCL9andCXCL10.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Schett,G.,etal.TherAdvMusculoskeletDis.2010;2(5):271-278.
ScientificCategory:
PDEInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
