Bpsbioscience/CD39，His标签（人类）/71284/50µg
商品编号：
71284
品牌：
bpsbioscience
市场价：
¥6500.00
美元价：
3900.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: Expi293
MW: 51 kDa
Genbank #: NM_001776
Tag(s): C-terminal His-tag
a.a: 38-478
Background:
CD39 contributes to immune regulation through the hydrolysis of ATP to AMP in the rate limiting step of extracellular adenosine production. CD39 is expressed on the surface of multiple cells of the immune system including T-cells, Natural killer cells, B-cells, dendritic cells and macrophages. In addition, high levels of CD39 expression have been associated with the tumor microenvironment (TME). Research aimed at reducing immunosuppression by CD39 activity has resulted in the study of a small molecule inhibitor, POM1, and multiple anti-CD39 antibodies selected for blocking enzymatic activity or decreasing CD39 expression.
Description:
Human CD39, also known as Cluster of Differentiation 39, GenBank Accession number NM_001776, a.a. 38-478 with C-terminal His-tag. MW = 51 kDa, expressed in an Expi293 expression system. This protein runs at a higher MW
by SDS-PAGE due to glycosylation.
Specific Activity:
≥3000 pmol/min/μg
Assay Conditions:
Add CD39 enzyme to 50 μl reaction mix containing 0.5 mM ATP and 10 mM CaCl2. Incubate 1h at RT with slow shaking. Add 50 μl GLO Max to every well. Finally, read luminescence.
Formulation:
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Storage / Stability:
At least 6 months at –80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary use carrier protein (BSA 0.1 – 0.5%).
Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
1. Deaglio, S. et al., Journal of Environmental Medicine. 2007 Jun 204(6): 1257-1265.
2. Borsellino, G. et al., Blood. 2007 Aug; 110(4):1225-1232.
Scientific Category:
Immunotherapy
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
