4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Routine_cell_strain > Bpsbioscience/CD155/TCR激活剂-CHO重组细胞系/60548/2小瓶
商品详细Bpsbioscience/CD155/TCR激活剂-CHO重组细胞系/60548/2小瓶
Bpsbioscience/CD155/TCR激活剂-CHO重组细胞系/60548/2小瓶
Bpsbioscience/CD155/TCR激活剂-CHO重组细胞系/60548/2小瓶
商品编号: 60548
品牌: bpsbioscience
市场价: ¥176000.00
美元价: 105600.00
产地: 美国(厂家直采)
公司:
产品分类: 常规细胞株
公司分类: Routine_cell_strain
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Background:
TIGITisaco-inhibitoryreceptorthatishighlyexpressedinNaturalKiller(NK)cells,activatedCD4+,CD8+andregulatoryTcells.Interactionwiththepoliovirusreceptor(PVR;CD155)onantigenpresentingcells,suchasdendriticcells,recruitsSrchomology(SH)domain-containingproteintyrosinephosphataseSHP1andSHP2ortheinositolphosphataseSHIP1andSHIP2totheTIGITITIMdomain.ThisincreasesIL-10releaseandsuppressesNF-kBandNFATTcellreceptor(TCR)signaling,whichblocksTcellproliferationandcytokineproduction.ItservesasacompetitiveinhibitorofCD226,aco-stimulatoryreceptorforCD155.TIGITtargetingantibodiesthatblockthisTcell-intrinsicinhibitoryeffectshaveshownenhancedanti-tumorandanti-viralfunctionsinpreclinicalstudies.
Description:
RecombinantCHO-K1cellsconstitutivelyexpressinghumanCD155(Poliovirusreceptor,Nectin-likeprotein5,GenBankaccession#NM_006505)andanengineeredTcellreceptor(TCR)activator.
Synonym(s):
Poliovirusreceptor(PVR)andNectin-likeprotein5
HostCellline:
CHO
MycoplasmaTesting:
ThecelllinehasbeenscreenedusingthePCR-basedVenor®GeMMycoplasmaDetectionkit(Sigma-Aldrich)toconfirmtheabsenceofMycoplasmaspecies.
Instructionsforuse:
Seeproductdatasheetfordetailedprotocol.
Storage/StABIlity:
Storeinliquidnitrogenimmediatelyuponreceipt.
Application(s):
ScreenforactivatorsorinhibitorsofTIGITsignalinginacellularcontext,screenCD155antibodiesforbindingaffinity,andcharacterizetheBIOLOGicalactivityofTIGITinteractionswithCD155
Notes:

Contactusforpricing.

LicenseDisclosure:Purchaseofthiscelllinegrantsyouwitha10-yearlicensetousethiscelllineinyourimmediatelaboratory,forresearchuseonly.Thislicensedoesnotpermityoutoshare,distribute,sell,sublicense,orotherwisemakethecelllineavailableforusetootherlaboratories,departments,researchinstitutions,hospitals,universities,orbiotechcompanies.Thelicensedoesnotpermituseofthiscelllineinhumansorfortherapeuticordruguse.Thelicensedoesnotpermitmodificationofthecelllineinanyway.InappropriateuseordistributionofthiscelllinewillresultinrevocationofthelicenseandresultinanimmediateceaseofsalesanddistributionofBPSproductstoyourlaboratory.BPSdoesnotwarrantthesuitabilityofthecelllineforanyparticularuse,anddoesnotacceptanyliabilityinconnectionwiththehandlingoruseofthecellline.Modificationsofthiscellline,transfertoanotherfacility,orcommercialuseofthecellsmayrequireaseparatelicenseandadditionalfees;contactsales@bpSBIoscience.comfordetails.PublicationsusingthiscelllineshouldreferenceBPSBioscience,Inc.,SanDiego.

Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Immunotherapy
ProductType:
CellLine
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。