Bpsbioscience/c-Mer、GST标签（人类）/40254/10和micro；G
商品编号：
40254
品牌：
bpsbioscience
市场价：
¥7700.00
美元价：
4620.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:60kDa
Genbank#:NM_006343
Tag(s):N-terminalGST-tag
a.a:578–872
Background:
c-MERisatyrosinekinaseandamemberoftheMER/AXL/TYRO3receptorkinasefamily(1).Thec-MERgeneencodesatransmembraneproteinwithtwofibronectintype-IIIdomains,twoIg-likeC2-typedomains,andonetyrosinekinasedomain.Functionalknockoutofc-MERinmiceshowsthemicetohavemacrophagesdeficientintheclearanceofapoptoticthymocytestherebydemonstratingthecriticalroleforc-MERintheengulfmentandefficientclearanceofapoptoticcells.Defectsinc-MERhavebeenassociatedwithretinitispigmentosa,aphenotypethatcanbereversedbyreplacementofthec-MERgeneproduct(2).
Description:
Humanc-Mer,alsoknownastyrosine-proteinkinaseMer,MERTK,andreceptortyrosinekinaseMerTKGenBankAccessionNM_006343,a.a.578-872withCterminalGST-tag.Expressedinabaculovirus-infectedSf9cellexpressionsystem.MW=60kDa.
UniProt
Q12866
Synonym(s):
tyrosine-proteinkinaseMer,MERTK,receptortyrosinekinaseMerTK
SpecificActivity:
≥50pmol/min/µg
AssayConditions:
Assaywasdoneinkinasebuffercontaining1mMDTTusingPoly-(Glu4:Tyr)substrate(0.2mg/ml)and20μMATP.Reactionwasdoneat30°Cfor45min.AmountofATPtransferredwascalculatedusingKinase-Gloreagent(Promega).
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,0.04%Tween20,20%glycerol,and1.6mMglutathione
Format:
Aqueousbuffersolution
Storage/StABIlity:
Atleast6monthsat–80°C.
Application(s):
Usefulforthestudyofenzymekineticsandforinhibitorscreening.
Reference(s):
1.VanHoof,C.etal.,Genomics.1995;28:261-272.
2.Chao,Y.etal.,Molec.Cell.2006;23:535-546.
2.Chao,Y.etal.,Molec.Cell.2006;23:535-546.
Warning(s):
Avoidfreeze/thawcycles.Storingdilutedproteinisnotrecommended,ifnecessary,usecarrierprotein(BSA0.1–0.5%).
ScientificCategory:
Kinase/ReceptorTyrosine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
