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当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/Posaconazole/27639-1/5 mg
商品详细Bpsbioscience/Posaconazole/27639-1/5 mg
Bpsbioscience/Posaconazole/27639-1/5 mg
Bpsbioscience/Posaconazole/27639-1/5 mg
商品编号: 27639-1
品牌: bpsbioscience
市场价: ¥2900.00
美元价: 1740.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
MW: 700.78 Da
CAS Registry #: 171228-49-2
Formula: C37H42F2N8O4
Target: CYP51A1
Background:
Posaconazole, also known as SCH 56592 or Noxafil, is a novel triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi. Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth.
Description:
A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.
Synonym(s):
Noxafil; SCH 56592; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
Purity:

≥98% by HPLC

Biological Activity:
Posaconazole inhibits growth of Candida (C. albicans C43, C. albicans C288, C. albicans C600 and C. albicans C248) and Aspergillus (A. fumigatus ND158 and A. flavus ND134), with IC50 of 0.007 µg/ml, 0.06 µg/ml, 0.2 µg/ml, 0.3 µg/ml, 0.03 µg/ml and 0.03 µg/ml, respectively.
Solubility:
Soluble in DMSO
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):
1. Hanan K. et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2004; 48(10): 3690-3696.
2. Daryl S. et al. Clinical Therapeutics. 2007; 29(9): 1862-1886.
Scientific Category:
Demethylase Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。