Bpsbioscience/泊沙康唑/27639-2/25 mg
商品编号：
27639-2
品牌：
bpsbioscience
市场价：
¥10100.00
美元价：
6060.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:700.78Da
CASRegistry#:171228-49-2
Formula:C37H42F2N8O4
Target:CYP51A1
Background:
Posaconazole,alsoknownasSCH56592orNoxafil,isanoveltriazoleantifungalcompoundthatpotentlyinhibits14α-demethylationinavarietyoffungi.Posaconzole,anitraconzolederivativewithfluorinereplacingchlorineinthephenylringandhydroxylationinthesidechain,bindstothehemecofactorontheactivesiteof14α-demethylase,whichconvertslanosterolto14α-dimethylanosterol,resultinginthedisruptionoftheintegrityandfunctionofthefungalcellmembraneandinhibitionoffungalgrowth.
Description:
AsterolC14?demethylaseinhibitorwithanIC50of0.25nM.Anti-fungalusedtopreventseriousfungalinfectionsinpeoplewithaweakenedABIlitytofightinfectionandtotreatyeastinfections.
Synonym(s):
Noxafil;SCH56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
Purity:
≥98%byHPLC
BIOLOGicalActivity:
PosaconazoleinhibitsgrowthofCandida(C.albicansC43,C.albicansC288,C.albicansC600andC.albicansC248)andAspergillus(A.fumigatusND158andA.flavusND134),withIC50of0.007µg/ml,0.06µg/ml,0.2µg/ml,0.3µg/ml,0.03µg/mland0.03µg/ml,respectively.
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.HananK.etal.ANTIMICROBIALAGENTSANDCHEMOTHERAPY.2004;48(10):3690-3696.
2.DarylS.etal.ClinicalTherapeutics.2007;29(9):1862-1886.
2.DarylS.etal.ClinicalTherapeutics.2007;29(9):1862-1886.
ScientificCategory:
DemethylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
