Bpsbioscience/GSK J4 HCl/27627-1/10 mg
商品编号：
27627-1
品牌：
bpsbioscience
市场价：
¥3500.00
美元价：
2100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:454Da
CASRegistry#:1373423-53-0
Formula:C24H27N5O2•HCl
Target:JMJD3,UTX
Background:
GSKJ4isapotentcell-permeableinhibitorofthehistoneH3lysine27(H3K27)demethylaseJMJD3.GSKJ4isanethylesterderivativeofGSKJ1,aJMJD3inhibitor(IC50=60nM)withrestrictedcellularpermeABIlityduetothehighlypolarcarboxylategroup,andrapidlyhydrolyzedbymacrophageesteraseuponadmiNISTrationleADIngtothegenerationofpharmacologicallyrelevantintracellularconcentrationofGSK-J1.GSKJ4hasbeenfoundtodose-dependentlyinhibittheproductionoftumor-necrosisfactor-α(TNF-α),aLPS-drivencytokineinvolvedinvariousfnflammatorydisorders(IC50=9µM).
Description:
GSKJ4HClisacellpermeableprodrugofGSKJ1,whichisthefirstselectiveinhibitoroftheH3K27histonedemethylaseJMJD3andUTXwithIC50of60nMandinactiveagainstapanelofdemethylasesoftheJMJfamily.
Synonym(s):
ethyl3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
Purity:
≥98%byHPLC
BIOLOGicalActivity:
InhibitsJMJD3andUTXwithIC50of60nMandinactiveagainstapanelofdemethylasesoftheJMJfamily(IC50value>50µM).
Solubility:
SolubleinDMSO84mg/ml,water84mg/ml,ethanol84mg/ml
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
KruidenierL,etal.Nature.2012Aug16;488(7411):404-8.
ScientificCategory:
DemethylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
