Bpsbioscience/Pracinostat（SB939）/27771-3/50毫克
商品编号：
27771-3
品牌：
bpsbioscience
市场价：
¥14000.00
美元价：
8400.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 358.48 Da
CAS Registry #: 929016-96-6
Formula: C20H30N4O2
Target: HDAC
Background:
Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones. It is a pan-HDAC inhibitor, inhibiting all HDAC isozymes except HDAC6 and HDAC7.
Description:
Potent and oral inhibitor of histone deacetylase (HDAC), selective for class I, II and IV HDACs. SB939 shows significant antiproliferative activity against a wide variety of tumor cell lines, with high tumor exposure and efficacy in mouse models of colorectal cancer.
Synonym(s):
SB-939; SB 939; (E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
Biological Activity:
SB 939 is an HDAC inhibitor that inhibits HDAC1 (IC50 = 49 nM), HDAC3 (IC50 = 43 nM), HDAC4 (IC50 = 56nM), HDAC5 (IC50 = 47 nM), HDAC9 (IC50 = 70 nM), HDAC10 (IC50 = 40 nM). Only poorly inhibits HDACs 6 or 7 (Kis = 247 and 104 nM, respectively). Prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT-116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.56, 0.48, and 0.34 µM, respectively.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Novotny-Diermayr V, et al. Mol Cancer Ther. 2010 Mar;9(3):642-52.
2. Wang, H., et al. 2011. J. Med. Chem. 54(17): 4694-4720.
3. Novotny-Diermayr V, et al. Blood Cancer J. 2012 May;2(5):e69.
2. Wang, H., et al. 2011. J. Med. Chem. 54(17): 4694-4720.
3. Novotny-Diermayr V, et al. Blood Cancer J. 2012 May;2(5):e69.
Scientific Category:
Deacetylase Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
