Bpsbioscience/Pracinostat (SB939)/27771-1/10 mg
商品编号：
27771-1
品牌：
bpsbioscience
市场价：
¥5500.00
美元价：
3300.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:358.48Da
CASRegistry#:929016-96-6
Formula:C20H30N4O2
Target:HDAC
Background:
Pracinostat(SB939)isanorallybioavailable,small-moleculehistonedeacetylase(HDAC)inhibitorwithpotentialantineoplasticactivity.PracinostatinhibitsHDACs,whichmayresultintheaccumulationofhighlyacetylatedhistones.Itisapan-HDACinhibitor,inhibitingallHDACisozymesexceptHDAC6andHDAC7.
Description:
Potentandoralinhibitorofhistonedeacetylase(HDAC),selectiveforclassI,IIandIVHDACs.SB939showssignificantantiproliferativeactivityagainstawidevarietyoftumorcelllines,withhightumorexposureandefficacyinmousemodelsofcolorectalcancer.
Synonym(s):
SB-939;SB939;(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
BIOLOGicalActivity:
SB939isanHDACinhibitorthatinhibitsHDAC1(IC50=49nM),HDAC3(IC50=43nM),HDAC4(IC50=56nM),HDAC5(IC50=47nM),HDAC9(IC50=70nM),HDAC10(IC50=40nM).OnlypoorlyinhibitsHDACs6or7(Kis=247and104nM,respectively).Preventsproliferationofovarian(A2780),colon(COLO205andHCT-116),andprostatecancer(PC-3)celllinesatIC50valuesof0.48,0.56,0.48,and0.34µM,respectively.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Novotny-DiermayrV,etal.MolCancerTher.2010Mar;9(3):642-52.
2.Wang,H.,etal.2011.J.Med.Chem.54(17):4694-4720.
3.Novotny-DiermayrV,etal.BloodCancerJ.2012May;2(5):e69.
2.Wang,H.,etal.2011.J.Med.Chem.54(17):4694-4720.
3.Novotny-DiermayrV,etal.BloodCancerJ.2012May;2(5):e69.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
