Bpsbioscience/PCI-24781 (CRA-024781)/27769-2/50 mg
商品编号：
27769-2
品牌：
bpsbioscience
市场价：
¥9900.00
美元价：
5940.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:397.4Da
CASRegistry#:783355-60-2
Formula:C21H23N3O5
Target:HDAC
Background:
PCI-24781isapan-HDACinhibitorthatshowsantitumoractivityinvitroandinvivopreclinicallyandisunderevaluationinphaseIclinicaltrialsforcancer,particularlyB-celllymphoma.PCI-24781inducescaspaseandreactiveoxygenspecies-dependentapoptosisthroughNF-?BmechanismsinHodgkinlymphomaandnon-Hodgkinlymphomacelllines.
Description:
PCI-24781(alsoknownasCRA-024781)isanovel,broadspectruminhibitorofHDACsthatshowsantitumoractivityinvitro.PCI-24781primarilytargetsHDAC1(Ki=7nM).ItalsoexhibitsmodestpotentytowardHDACs2,3,6,and10andgreaterthan40-foldselectivityagainstHDAC8.
Synonym(s):
PCI-24781;CRA-024781;Abexinostat
BIOLOGicalActivity:
PCI-24781inhibitedpurerecombinantHDAC1withaKiof(Ki=7nM),aswellasHDAC2,HDAC3/SMRT,HDAC6,HDAC8,andHDAC10inthenanomolarrange.AntitumoractivityofPCI-24781wasobservedinall10tumorcelllinestested,withGI50%valuesrangingfrom0.15to3.09µM.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.BuggyJJ,etal.MolCancerTher,2006,5(5),1309-1317.
2.BhallaS,etal.ClinCancerRes,2009,15(10),3354-3365.
2.BhallaS,etal.ClinCancerRes,2009,15(10),3354-3365.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
