Bpsbioscience/MC1568/27761-2/25 mg
商品编号：
27761-2
品牌：
bpsbioscience
市场价：
¥3900.00
美元价：
2340.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:314.3Da
CASRegistry#:852475-26-4
Formula:C17H15FN2O3
Target:HDAC
Background:
MC1568,aderivativeof(Aryloxopropenyl)pyrrolylhydroxyamide,isanovel,potentandspecificinhibitorofclassIIhistonedeacetylase(HDAC),includingtwosubclassesIIa(HDAC4,HDAC5,HDAC6,HDAC7andHDAC9)andIIb(HDAC6andHDAC10),thatexhibitsstronginhibitionagainstmaizeclassIIHDACwith50%inhibitionconcentrationIC50valueof22µM.MC1568hasbeenfoundtotissue-selectivelyinhibitsHDACandarrestmyogenesisinculturedmusclecellsthroughthreepossIBLemechanisms,includingdecreasingtheexpressionofmyocyteenhancerfactor2D,stABIlizingtheHDAC-HDAC3-MEF2Dcomplexandinhibitingtheacetylationofdifferentiation-inducedMEF2D.Moreover,MC1568isabletointerferewithRAR-andPPARγ-mediateddifferentiation-inducingsignalingpathways.
Description:
SelectiveinhibitorofclassIIahistonedeacetylases(HDACs).Exhibitstissue-selectiveinhibitionbetweenmembersofclassIIdeacetylasesinvivo;inhibitsHDAC4andHDAC5inskeletalmuscleandtheheartwithoutaffectingHDAC3activity.DisplaysnoinhibitionofclassIHDACactivity(HDAC1,2,3)orexpression.
Synonym(s):
MC1568;MC-1568;(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.MaiA,etal.JMedChem.2005May5;48(9):3344-53.
2.NEBbiosoA,etal.JMolEndocrinol.2010Oct;45(4):219-28.
3.NebbiosoA,etal.EMBORep.2009Jul;10(7):776-82.
2.NEBbiosoA,etal.JMolEndocrinol.2010Oct;45(4):219-28.
3.NebbiosoA,etal.EMBORep.2009Jul;10(7):776-82.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
