Bpsbioscience/LAQ824 (NVP-LAQ824,Dacinostat)/27760-1/10 mg
商品编号：
27760-1
品牌：
bpsbioscience
市场价：
¥5200.00
美元价：
3120.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:379.5Da
CASRegistry#:404951-53-7
Formula:C22H25N3O3
Target:HDAC
Background:
ArecentstudyshowsthatLAQ824induceschromatinchangesattheleveloftheIL-10genepromoterthatleadtoenhancedrecruitmentofthetranscriptionalrepressorsHDAC11andPU.1andinhibitsIL-10productioninBALB/cmurinemacrophages.
Description:
LAQ824(alsoknownasNVP-LAQ824orDacinostat),aderivativeof4-aminomethylcinnamichydroxamicacid,isanovelandpotentinhibitorofhistonedeacetylase(HDAC)thatinhibitstheactivityofHDACwithIC50valueof0.03µM.
Synonym(s):
LAQ824;NVP-LAQ824;Dacinostat;
BIOLOGicalActivity:
LAQ824(NVP-LAQ824)isanovelHDACinhibitorwithIC50of32nM.LAQ824activatesthep21promoterwith50%ofthemaximalpromoteractivation(AC50)of0.30µM,whichinturn,activatesthep21inhibitorgene.LAQ824hasbeenfoundtoinhibitthegrowthofavarietyofcancercelllines,includingH1299,anon-smallcelllungcarcinomaline,andHCT116,acoloncancercelllinewithIC50of0.15µMand0.01µM,respectively.LAQ824alsodose-andtime-dependentlyinhibitsthecellgrowthofbreastcancerMDA435cells,prostatecancerDU145andPC3cellsandnon-smallcelllungcancerA549cells,withIC50value<1µMandinduceapoptosisinhumanbreastcancerSKBR-3,BT-474andMB-468cells.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
CatleyL,etal.Blood.2003Oct1;102(7):2615-22.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
