Bpsbioscience/JNJ-26481585/27632-1/5 mg
商品编号：
27632-1
品牌：
bpsbioscience
市场价：
¥4700.00
美元价：
2820.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:394.5Da
CASRegistry#:875320-29-9
Formula:C21H26N6O2
Target:HDAC
Background:
Quisinostat,alsoknownasJNJ-26481585,isanorallybioavailable,second-generation,hydroxamicacid-basedinhibitorofhistonedeacetylase(HDAC)withpotentialantineoplasticactivity.HDACinhibitorJNJ-26481585inhibitsHDACleADIngtoanaccumulationofhighlyacetylatedhistones,whichmayresultinaninductionofchromatinremodeling;inhibitionofthetranscriptionoftumorsuppressorgenes;inhibitionoftumorcelldivision;andtheinductionoftumorcellapoptosis.HDAC,anenzymeupregulatedinmanytumortypes,deacetylateschromatinhistoneproteins.ComparedtosomefirstgenerationHDACinhibitors,JNJ-26481585mayinducesuperiorHSP70upregulationandbcl-2downregulation.
Description:
JNJ-26481585,alsoknownasQuisinostat,isapotentpan-HDACinhibitor.JNJ-26481585induceshistoneacetylationandinhibitscancercellproliferation.
Synonym(s):
Quisinostat;N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide
Purity:
≥98%byHPLC
BIOLOGicalActivity:
JNJ-26481585inhibitsHDAC1,HDAC2,HDAC4,HDAC10,andHDAC11withIC50valuesof0.11nM,0.33nM,0.64nM,0.46nM,and0.37nM,respectively.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Rajak,H.,etal.CurrMedChem.2014;21(23):2642-64.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
