4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/HDAC3/NcoR2 Complex, His-tag/50003/50 µg
商品详细Bpsbioscience/HDAC3/NcoR2 Complex, His-tag/50003/50 µg
Bpsbioscience/HDAC3/NcoR2 Complex, His-tag/50003/50 µg
Bpsbioscience/HDAC3/NcoR2 Complex, His-tag/50003/50 µg
商品编号: 50003
品牌: bpsbioscience
市场价: ¥8800.00
美元价: 5280.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:87.3kDa(complex)
Genbank#:NM_003883
Tag(s):C-terminalHis-tag
a.a:fulllengthHDAC3,395–489NCOR2
Description:
ComplexofhumanHDAC3,GenBankAccessionNo.NM_003883,fulllengthwithC-terminalHis-tag,MW=49.7kDa,andhumanNCOR2,a.a.395-489,GenBankAccessionNo.NM_006312,N-terminalGST-tag,MW=37.6kDa,co-expressedinbaculovirusexpressionsystem.
UniProt
O15379
Synonym(s):
histonedeacetylase3,HDAC-3
SpecificActivity:
≥3000pmol/min/µg.
AssayConditions:
25mMTris/HCl,pH8.0,137mMNaCl,2.7mMKCl,1mMMgCl2,and0.1mg/mlBSA,20µMBPSHDACsubstrate3(Catalog#50037),andHDAC3/NcoR2.Incubationcondition:30minat37°C,followedbyHDACdeveloper(Catalog#50030)for15minatroomtemperature.Fluorescenceintensityismeasuredatex360/em460.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,20%glycerol,200mMimidazole
Format:
Aqueousbuffersolution
Storage/StABIlity:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):

1.Gregoire,S.etal.Mol.Cell.Biol.27(4),1280-1295(2007)
2.Escaffit,F.etal.,Mol.Cell.Biol.27(2),554-567(2007)

ApplicationReference(s):
1. SelectivityandKineticRequirementsofHDACInhibitorsasProgranulinEnhancersforTreatingFrontotemporalDementia(2017)
2. AnazumamideCanaloguewithoutthezinc-bindingfunctionality(2017)
3. MolecularSimulationandActivityStudiesofOxametacinasanHDACInhibitor(2017)
4. Impactofbindingmechanismonselectiveinhibitionofhistonedeacetylaseisoforms(2017)
5. Design,synthesisandBIOLOGicalevaluationofnovelhydroxamicacidbasedhistonedeacetylase6selectiveinhibitorsbearingphenylpyrazolscaffoldassurfacerecognitionmotif(2017)
6.IdentificationofhistonedeacetylaseinhibitorswithbenzoylhydrazidescaffoldthatselectivelyinhibitclassIhistonedeacetylases(2015)
7.MechanismofActionof2-AminobenzamideHDACInhibitorsinReversingGeneSilencinginFriedreich"sAtaxia(2015)
8.Design,synthesis,3Dpharmacophore,QSAR,anddockingstudiesofcarboxylicacidderivativesasHistoneDeacetylaseinhibitorsandcytotoxicagents(2014)
9.DiscoveryofasmallmoleculeagoNISTofphosphatidylinositol3-kinasep110αthatreactivateslatentHIV-1(2014)
10.AchimericSERM-histonedeacetylaseinhibitorapproachtobreastcancertherapy(2014)
11.InVivoImagingofHistoneDeacetylases(HDACs)intheCentralNervousSystemandMajorPeripheralOrgans(2014)
12.SelectiveHDACInhibitionfortheDisruptionofLatentHIV-1Infection(2014)
13.ClassIHDACimagingusing[(3)H]CI-994autorADIography(2013)
14.Crebinostat:anovelcognitiveenhancerthatinhibitshistonedeacetylaseactivityandmodulateschromatin-mediatedneuroplasticity(2013)
15.FDG-PETimagingrevealslocalbrainglucoseutilizationisalteredbyclassIhistonedeacetylaseinhibitors(2013)
16.HighlyligandefficientandselectiveN-2-(Thioethyl)picolinamidehistonedeacetylaseinhibitorsinspiredbythenaturalproductpsammaplinA(2013)
17.ImagingepigeneticregulationbyhistonedeacetylasesinthebrainusingPET/MRIwith¹⁸F-FAHA(2013)
18.Structuralbasisfortheinhibitionofhistonedeacetylase8(HDAC8),akeyepigeneticplayerinthebloodflukeSchistosomamansoni(2013)

Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Deacetylase
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。