Bpsbioscience/EX527/27103/1毫克
商品编号：
27103
品牌：
bpsbioscience
市场价：
¥3700.00
美元价：
2220.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 248.7 Da
CAS Registry #: 49843-98-3
Formula: C13H13ClN2O
Description:
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation.
Purity:
≥99% by HPLC
Biological Activity:
EX-527 inhibits SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. IC50 values are 98 nM, 19.6 µM, 48.7 µM, >100 µM and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively.
Solubility:
Soluble in DMSO.
Format:
White to beige powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Solomon, JM et al. Mol Cell Biol. 2006 Jan;26(1):28-38
2. Huhtiniemi, T et al. J Med Chem. 2008 Aug 14;51(15):4377-80
Application Reference(s):
1. Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion (2017)
Scientific Category:
HDAC
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
