Bpsbioscience/CUDC-907/27616-3/50 mg
商品编号：
27616-3
品牌：
bpsbioscience
市场价：
¥14100.00
美元价：
8460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 508.6 Da
CAS Registry #: 1339928-25-4
Formula: C23H24N8O4S
Target: HDAC, PI3K
Background:
CUDC-907 has a long half-life in murine tumors. CUDC-907 induces apoptosis and inhibits cancer cell proliferation in xenograft tumors.
Description:
CUDC-907 is a dual PI3K and HDAC inhibitor
Synonym(s):
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
Purity:
≥98% by HPLC
Biological Activity:
CUDC-907 inhibits HDAC1, 2, 3, 6, 8, 10, and 11 with IC50 of 1.7 nM, 5 nM, 1.8 nM, 27 nM, 191 nM, 2.8 nM, and 5.4 nM, respectively. CUDC-907 inhibits PI3Kα (IC50 of 19 nM) and other PI3K isoforms such as PI3Kβ, PI3Kγ, PI3Kδ, PI3KαH1047R and PI3KαE545K with IC50 of 54 nM, 311 nM, 39 nM, 73 nM and 62 nM, respectively. CUDC-907 suppresses other types of HDAC enzymatic activity with lower potency.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Qian C, et al. Clin Cancer Res. 2012 Aug 1;18(15):4104-13.
Scientific Category:
Deacetylase Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
