Bpsbioscience/Chidamide/27202/1 mg
商品编号：
27202
品牌：
bpsbioscience
市场价：
¥2400.00
美元价：
1440.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:390.4Da
CASRegistry#:743420-02-2
Formula:C22H19FN4O2
Description:
ChidamideisahistonedeacetylaseinhibitorwhichincreasesHistoneH3acetylationlevelsinLoVoandHT29coloncancercellsatlowconcentrations(4µM).Chidamideaffectstheactivationofoncogenicsignalingkinasesbydose-dependentlyreducingphosphorylatedAkt,mTOR,p70S6K,RafandErk1/2proteinexpressionincoloncancercells.Chidamidealsodose-dependentlyupregulatesp21proteinexpression,down-regulatesCDK4,andinducescellcyclearrestattheG0/G1phase.
Purity:
≥98%byHPLC.
BIOLOGicalActivity:
ChidamidehasshownanIC50rangingfrom1–13µMusinganMTTassayperformedonhumancancercelllines.
Solubility:
SolubleinDMSOandDMF.Sparinglysolubleinaqueousbuffers.Formaximumsolubility,dissolvefirstinDMSOandthendilutewithaqueousbufferofchoice.
Format:
Whitetooff-whitecrystallinesolid.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Liu,L.,etal.,Biochem.Biophys.Res.Commun.2010;392:190-195.
2.Wang,H.,etal.,MolMedReport.2012Apr5.doi:10.3892/mmr.2012.858.[Epubaheadofprint]
2.Wang,H.,etal.,MolMedReport.2012Apr5.doi:10.3892/mmr.2012.858.[Epubaheadofprint]
ScientificCategory:
HDAC
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
