Bpsbioscience/Belinostat（PXD101）/27608-3/100 mg
商品编号：
27608-3
品牌：
bpsbioscience
市场价：
¥8900.00
美元价：
5340.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:318.4Da
CASRegistry#:414864-00-9
Formula:C15H14N2O4S
Target:HDAC
Background:
BelinostathasbeenfoundtosignificantlyincreasetheacetylationofhistonesH3andH4andexertscytotoxicityinawiderangeoftumorcelllines.
Description:
Belinostat,alsoknownasPXD101,isanovelandpotenthydroxamate-typeHDACinhibitor.
Synonym(s):
PXD-101,PXD101,PX105684,PX-105684,(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
Purity:
≥98%byHPLC
BIOLOGicalActivity:
Belinostat(alsoknownasPXD101)isanovelandpotenthydroxamate-typeinhibitorofhistonedeacetylase(HDAC)thatinhibitstheactivityofHDACinHelacellextractswithIC50valueof27nM.Inthetreatmentofurothelialcarcinomacelllines,belinostatdose-dependentlyinhibitsproliferationin5637,T24,J82andRT4cellswithIC50valuesof1.0µM,3.5µM,6.0µMand10µMrespectively;while,inprostatecancercelllines,itinhibitscancercellgrowthwithIC50valuesrangingfrom0.5to2.5µM.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Buckley,MT,etal.J.Transl.Med.2007;5:49.
2.Gravina,GLetal.Int.J.Oncol.40:711-720,2012.
3.PlumbJA,etal.MolCancerTher.2003Aug;2(8):721-8.
2.Gravina,GLetal.Int.J.Oncol.40:711-720,2012.
3.PlumbJA,etal.MolCancerTher.2003Aug;2(8):721-8.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
