Bpsbioscience/Human Interleukin-21/90186-A/2 µg
商品编号：
90186-A
品牌：
bpsbioscience
市场价：
¥2600.00
美元价：
1560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: E. coli
MW: 15 kDa
Genbank #: Q9HBE4
a.a: 25–155
Background:
IL-21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T-cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on NK-cells, T- cells, and B-cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3.
Description:
Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.
UniProt
Q9HBE4
Synonym(s):
Interleukin 21, IL-21, Za11
Purity:
≥97% by SDS-PAGE and HPLC
Endotoxin Level:
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity:
The ED50 was determined by the dose-dependent proliferation of activated B-cells.
Formulation:
Lyophilized from 0.2 µm filtered PBS, pH 7.5.
Format:
lyophilized protein
Reconstitution:
Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability:
The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.
Reference(s):
1. Pallikkuth, S., et al. Crit Rev Immunol. 2012,32(2):173-95.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70.
3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70.
3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6.
Warning(s):
Avoid freeze/thaw cycles
Amino Acid Sequence:
QDRHMI RMRQLIDIVD QLKNYVNDLV PEFLPAPEDV ETNCEWSAFS CFQKAQLKSA NTGNNERIIN VSIKKLKRKP PSTNAGRRQK HRLTCPSCDS YEKKPPKEFL ERFKSLLQKM IHQHLSSRTH GSEDS
Scientific Category:
Cytokine/Growth Factors
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
